Mauro Camoranesi tucked away Pavel Nedved's pull-back for his first domestic goal of the season on 28 minutes. Pinto Santos struck the crossbar for Juve but it was La Vecchia Signora who doubled their lead moments before half time.

Juve, beaten 1-0 at Inter last weekend, made it three when defender Giorgio Chiellini glanced in Marco Marchionni's free kick just past the hour.

Del Piero netted his 250th Juve goal with a penalty after a dubious foul on Sebastian Giovinco on 74 minutes.

Now Juve are three points adrift of Inter in second while Reggina were left in the drop zone third from bottom.

At Catania, Lecce rose a place into 16th and two points ahead of Reggina. Jose Castillo levelled for Lecce in the 68th minute just eight minutes after Michele Paolucci put the Sicilian side ahead.